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GhrelinGhrelin was discovered as the peptide hormone that potently stimulates release of growth hormone from the anterior pituitary. It has significant effects on appetite and generates hunger feeling.Obese people have lower than normal Ghreln levels, anorexic people have higher levels. Ghrelin peaks before a meal and meal intake reduces its level. Synthesis of ghrelin occurs predominantly in epithelial cells lining the fundus of the stomach. What is Ghrelin?Ghrelin is synthesized as a preprohormone, then proteolytically processed to yield a 28-amino acid peptide. An interesting and unique modification is imposed on the hormone during synthesis in the form of an n-octanoic acid bound to one of its amino acids; this modification is necessary for biologic activity. |
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Copyright 2004 Dr Angie Hayes |  |